Sedation and Plasma Concentration of Clonidine Hydrochloride for Pre-anesthetic Medication in Pediatric Surgery.

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Sedation and plasma concentration of clonidine hydrochloride for pre-anesthetic medication in pediatric surgery.

Clonidine hydrochloride has been used for pre-anesthetic medication to provide a pre-operative sedation in pediatric surgery. The purpose of this study is to determine the plasma clonidine concentration, which gives satisfactory sedation in pediatric surgery. Sixteen pediatric patients (age: 1-11 years, weight: 9-33 kg) received either 2 or 4 microg/kg of clonidine lollipop before entering the ...

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Objectives Pre- and post-sedation effect of oral Midazolam to promethazine in2-6 yrs old fearful children for dental treatment Methods This randomized clinical trial was carried out on a group of 26 children aged 2-6 years referred to the dental school due to their fear and multiple dental needs. Patients were selected from ASA I or II classification and scored 1 in Frankl Behavior scale. Each...

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Method validation of clonidine hydrochloride in human plasma by LC-MS technique

A simple and sensitive high performance liquid chromatography-electrospray ionization mass spectrometry method has been evaluated for the assignment of clonidine hydrochloride in human plasma. The mobile phase composed of acetonitrile–water 60:40 (v/v), and 0.2% formic acid 20 µL of sample was chromatographically analyzed using a repacked ZORBAX-XDB-ODS C18 column (2.1 mm×30 m...

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Plasma concentration and local anesthetic activity of procaine hydrochloride following subcutaneous administration to horses.

OBJECTIVE To determine the durations of the local anesthetic effect and plasma procaine concentrations associated with 5- and 10-mg doses of procaine hydrochloride (with or without 100 microg of epinephrine) administered SC over the lateral palmar digital nerves of horses. ANIMALS 6 healthy adult horses. PROCEDURES The hoof withdrawal reflex latency (HWRL) period was determined by use of a ...

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ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 2003

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.26.421